We are pleased to announce our research paper has been published in a scientific journal.

Tezuka T, Arakawa H, Kudo K, Takehara H, Morioka M, Ikeda K, Ikeda T, Yasuda K, Fujima Y, Kobayashi M, Okada Y, Arai T, Arai S, Miyazaki T. A clinical impact of apoptosis inhibitor of macrophage on feline chronic kidney disease. Vet J. 2026, 315, 106545.

We are pleased to announce that the clinical trial for the AIM cat medicine has officially started at 26 veterinary hospitals across Japan. We are deeply grateful for your continued support.
We are fully committed to ensuring the trial progresses smoothly and to obtaining approval as soon as possible. We kindly ask for your continued support and encouragement as we move forward.

A research paper, in collaboration with Prof. Miyake from The Institute of Medical Science, The University of Tokyo, has been published in a scientific journal.

Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025, 222, 20230647.

We are pleased to announce our research paper has been published in a scientific journal.

Yasuda K, Nishijima A, Inoue T, Takagi T, Tanabe K, Minakuchi J, Arai S, Miyazaki T. Release of apoptosis inhibitor of macrophage (AIM) from pentameric IgM in serum predicts prognosis after hemodialysis initiation. Commun Med. 2025, 5, 15.

We are pleased to announce our research paper has been published in a scientific journal.

Press release is available in Japanese.

Chen Q, Ishii K, Mori H, Nishijima A, Arai S, Miyazaki T, Rosenthal PB. Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M. Nat Commun. 2024, 15, 9387.

We are pleased to announce our research paper has been published in a scientific journal.

Yasuda K, Shimodan S, Maehara N, Hirota A, Iijima R, Nishijima A, Mori H, Toyama R, Ito A, Yoshikawa Y, Arai S, Miyazaki T. AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions. J Autoimmun. 2024, 142, 103149.

Research Fellow Kai Kudo* was awarded the "Encouragement Award" by the Japan Society of Clinical Chemistry (JSCC) in 2023.
*At the time of application, he was affiliated with Tokai University School of Medicine.

We are delighted to introduce an English version to our institute's website.

We are pleased to announce our research papers have been published in scientific journals.

Okanoue T, Yamaguchi K, Shima T, Mitsumoto Y, Katayama T, Okuda K, Mizuno M, Seko Y, Moriguchi M, Itoh Y, Miyazaki T. Artificial intelligence/neural network system that accurately diagnoses hepatocellular carcinoma in nonalcoholic steatohepatitis.
Hepatol Res. 2023, Online ahead of print.

Nemoto H, Honjo M, Arai S, Miyazaki T, Aihara M. Apoptosis inhibitor of macrophages/CD5L enhances phagocytosis in the trabecular meshwork cells and regulates ocular hypertension.
J Cell Physiol. 2023, Online ahead of print.

We are pleased to announce that FELISSIMO's "Neko-bu" (Cat club) has initiated the second phase of their AIM Medical Research Support Charity Project.
We extend our heartfelt gratitude for this initiative and assure you that IAM is dedicated to further accelerating drug development efforts.

For more information, please visit:
Neko-bu Blog
Special Website for AIM Medical Research Support Charity Project