A research paper, in collaboration with Prof. Miyake from The Institute of Medical Science, The University of Tokyo, has been published in a scientific journal.

Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025, 222, 20230647.

We are pleased to announce our research paper has been published in a scientific journal.

Yasuda K, Nishijima A, Inoue T, Takagi T, Tanabe K, Minakuchi J, Arai S, Miyazaki T. Release of apoptosis inhibitor of macrophage (AIM) from pentameric IgM in serum predicts prognosis after hemodialysis initiation. Commun Med. 2025, 5, 15.

We are pleased to announce our research paper has been published in a scientific journal.

Press release is available in Japanese.

Chen Q, Ishii K, Mori H, Nishijima A, Arai S, Miyazaki T, Rosenthal PB. Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M. Nat Commun. 2024, 15, 9387.

We are pleased to announce our research paper has been published in a scientific journal.

Yasuda K, Shimodan S, Maehara N, Hirota A, Iijima R, Nishijima A, Mori H, Toyama R, Ito A, Yoshikawa Y, Arai S, Miyazaki T. AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions. J Autoimmun. 2024, 142, 103149.

Research Fellow Kai Kudo* was awarded the "Encouragement Award" by the Japan Society of Clinical Chemistry (JSCC) in 2023.
*At the time of application, he was affiliated with Tokai University School of Medicine.

We are delighted to introduce an English version to our institute's website.

We are pleased to announce our research papers have been published in scientific journals.

Okanoue T, Yamaguchi K, Shima T, Mitsumoto Y, Katayama T, Okuda K, Mizuno M, Seko Y, Moriguchi M, Itoh Y, Miyazaki T. Artificial intelligence/neural network system that accurately diagnoses hepatocellular carcinoma in nonalcoholic steatohepatitis.
Hepatol Res. 2023, Online ahead of print.

Nemoto H, Honjo M, Arai S, Miyazaki T, Aihara M. Apoptosis inhibitor of macrophages/CD5L enhances phagocytosis in the trabecular meshwork cells and regulates ocular hypertension.
J Cell Physiol. 2023, Online ahead of print.

We are pleased to announce that FELISSIMO's "Neko-bu" (Cat club) has initiated the second phase of their AIM Medical Research Support Charity Project.
We extend our heartfelt gratitude for this initiative and assure you that IAM is dedicated to further accelerating drug development efforts.

For more information, please visit:
Neko-bu Blog
Special Website for AIM Medical Research Support Charity Project

We are delighted to share that Cygames Inc. has once again extended their generous support to us, building upon their previous year's contribution. On this occasion, we wish to convey our deep and heartfelt gratitude to Cygames Inc. The entire team at the research institute is wholeheartedly dedicated to advancing our efforts, aiming to finalize the development of AIM-based medication that holds the potential to revolutionize the treatment of both feline and human illnesses. Our utmost priority is to expedite the delivery of this groundbreaking solution to you, fulfilling the expectations you have kindly placed in us. We genuinely value your enduring support for IAM.
Warm regards,

Toru Miyazaki Director and President, IAM

We are pleased to announce that our institute has been designated as a research institution under Article 2 of the Regulations for the Handling of Grants-in-Aid for Scientific Research by the Ministry of Education, Culture, Sports, Science and Technology (MEXT).

Moving forward, we will continue to advance our research activities based on the established "Operation and Management of Public Research Funds and Measures Against Research Misconduct" framework within the institute.