We are pleased to announce our research paper has been published in a scientific journal.

Eguchi A, Maehara N, Hirota A, Yoshikawa Y, Yasuda K, Arai S, Miyazaki T. Identification of a novel glutamate receptor 2 mutation in mice presenting progressive cerebellar ataxia. Sci Rep. 2026, Online ahead of print.

We are pleased to announce our research paper has been published in a scientific journal.

Maehara N, Hattori S, Nakamura A, Nagatoishi S, Hirota A, Kudo K, Yoshikawa Y, Matsunaga R, Tsumoto K, Miyakawa T, Arai S, Miyazaki T. CD5L promotes phagocytic removal of amyloid β oligomers and improves cognitive function in a mouse model of Alzheimer's disease. Cell Rep. 2026, 45, 117468.

We are pleased to announce our research paper has been published in a scientific journal.

Kudo K, Ikeda T, Ikeda K, Maehara N, Hirota A, Yoshikawa Y, Mori H, Takayama M, Yasuda K, Tezuka T, Takagi T, Arai S, Miyazaki T. A kidney-protective mechanism via cellular oxidative stress reduction induced by CD5L protein. Cell Death Discov. 2026, 12, 311.

We are pleased to announce our research paper has been published in a scientific journal.

Tezuka T, Arakawa H, Kudo K, Takehara H, Morioka M, Ikeda K, Ikeda T, Yasuda K, Fujima Y, Kobayashi M, Okada Y, Arai T, Arai S, Miyazaki T. A clinical impact of apoptosis inhibitor of macrophage on feline chronic kidney disease. Vet J. 2026, 315, 106545.

We are pleased to announce that the clinical trial for the AIM cat medicine has officially started at 26 veterinary hospitals across Japan. We are deeply grateful for your continued support.
We are fully committed to ensuring the trial progresses smoothly and to obtaining approval as soon as possible. We kindly ask for your continued support and encouragement as we move forward.

A research paper, in collaboration with Prof. Miyake from The Institute of Medical Science, The University of Tokyo, has been published in a scientific journal.

Sato R, Liu K, Shibata T, Hoshino K, Yamaguchi K, Miyazaki T, Hiranuma R, Fukui R, Motoi Y, Fukuda-Ohta Y, Zhang Y, Reuter T, Ishida Y, Kondo T, Chiba T, Asahara H, Taoka M, Yamauchi Y, Isobe T, Kaisho T, Furukawa Y, Latz E, Nakatani K, Izumi Y, Nie Y, Taniguchi H, Miyake K. RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025, 222, 20230647.

We are pleased to announce our research paper has been published in a scientific journal.

Yasuda K, Nishijima A, Inoue T, Takagi T, Tanabe K, Minakuchi J, Arai S, Miyazaki T. Release of apoptosis inhibitor of macrophage (AIM) from pentameric IgM in serum predicts prognosis after hemodialysis initiation. Commun Med. 2025, 5, 15.

We are pleased to announce our research paper has been published in a scientific journal.

Press release is available in Japanese.

Chen Q, Ishii K, Mori H, Nishijima A, Arai S, Miyazaki T, Rosenthal PB. Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M. Nat Commun. 2024, 15, 9387.

We are pleased to announce our research paper has been published in a scientific journal.

Yasuda K, Shimodan S, Maehara N, Hirota A, Iijima R, Nishijima A, Mori H, Toyama R, Ito A, Yoshikawa Y, Arai S, Miyazaki T. AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions. J Autoimmun. 2024, 142, 103149.

Research Fellow Kai Kudo* was awarded the "Encouragement Award" by the Japan Society of Clinical Chemistry (JSCC) in 2023.
*At the time of application, he was affiliated with Tokai University School of Medicine.